Article
Evidence for correlations between BMI-associated SNPs and circRNAs.
Scientific reports - 25 Jul 2022
Rajcsanyi Luisa Sophie, Diebels Inga, Pastoors Lydia, Kanber Deniz, Peters Triinu, Volckmar Anna-Lena, Zheng Yiran, Grosse Martin, Dieterich Christoph, Hebebrand Johannes, Kaiser Frank J, Horsthemke Bernhard, Hinney Anke
Abstract excerpt
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. Analysis of sex-stratified GWAS data revealed that circRNA genomic loci encompassed more genome-wide significant...
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