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Article

Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms.

The Journal of biological chemistry - 27 Oct 2006

Hu Rong-Gui, Brower Christopher S, Wang Haiqing, Davydov Ilia V, Sheng Jun, Zhou Jianmin, Kwon Yong Tae, Varshavsky Alexander

Abstract excerpt

Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by the pathway's ubiquitin ligases. The conjugation of Arg is mediated by arginyltransferase, encoded by ATE1. Through its regulated degradation of specific...

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Identifiers

PMID: 16943202
DOI: 10.1074/jbc.M604355200

Genes

ATE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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