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Article

Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Fu Yaoyao, Kim Youngran, Jin Kyeong Sik, Kim Hyun Sook, Kim Jong Hyun, Wang DongMing, Park Minyoung, Jo Chang Hwa, Kwon Nam Hoon, Kim Doyeun, Kim Myung Hee, Jeon Young Ho, Hwang Kwang Yeon, Kim Sunghoon, Cho Yunje

Abstract excerpt

In higher eukaryotes, one of the two arginyl-tRNA synthetases (ArgRSs) has evolved to have an extended N-terminal domain that plays a crucial role in protein synthesis and cell growth and in integration into the multisynthetase complex (MSC). Here, we report a crystal structure of the MSC subcomp...

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Source

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Identifiers

PMID: 25288775
DOI: 10.1073/pnas.1408836111
PMCID: PMC4210331

Genes

AIMP1
MSC
AIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25288775-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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