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Family-based germline sequencing in children with cancer

10 Oct 2018

Abstract excerpt

The discovery of cancer-predisposing syndromes (CPSs) using next-generation sequencing (NGS) technologies is of increasing importance in pediatric oncology with regard to diagnosis, treatment, surveillance, family counselling and research. Recent studies indicate that a considerable percentage of childhood cancers are associated with CPSs. However, the ratio of CPSs that are caused by inherited vs. de novo...

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PMID: 30305723
DOI: 10.1038/s41388-018-0520-9

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