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Article

KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia

7 Jul 2022

Abstract excerpt

Loss-of-function mutations in the human potassium chloride cotransporter-3 (KCC3) cause a hereditary motor sensory neuropathy associated with agenesis of the corpus callosum. While recapitulating the neuropathy, KCC3-knockout mice also exhibit high blood pressure. This phenotype is believed to have neurogenic and/or vascular origins. The role of KCC3 in the kidney is poorly understood. KCC3 is encoded by two...

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PMID: 35874803
DOI: 10.3389/fcell.2022.931326

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