Article
K-Cl cotransport in red blood cells from patients with KCC3 isoform mutants.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Dec 2006
Lauf P K, Adragna N C, Dupre N, Bouchard J P, Rouleau G A
Abstract excerpt
Red blood cells (RBCs) possess the K-Cl cotransport (KCC) isoforms 1, 3, and 4. Mutations within a given isoform may affect overall KCC activity. In a double-blind study, we analyzed, with Rb as a K congener, K fluxes (total flux, ouabain-sensitive Na+/K+ pump, and bumetanide-sensitive Na-K-2Cl cotransport, Cl-dependent, and ouabain- and bumetanide-insensitive KCC with or without stimulation by N-ethylmaleimide...
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