KCC3 deficiency-induced disruption of paranodal loops and impairment of axonal excitability in the peripheral nervous system.

Abstract excerpt

The autosomal recessive Hereditary Motor and Sensory Neuropathy with Agenesis of the Corpus Callosum (HMSN/ACC) is associated with the dysfunction of the K(+)-Cl(-) cotransporter type 3 (KCC3), which is an electroneutral cotransporter. We previously found that the inhibition of KCC3 cotransporter activity reduces the propagation of action potentials in the peripheral nervous system (PNS). However, the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Action Potentials
• Share to Axons
• Share to Genotype