Article
Evolution of large extrachromosomal elements in HL-60 cells during culture and the associated phenotype alterations.
Biochemical and biophysical research communications - 2 Nov 2001
Haque M M, Hirano T, Itoh N, Utiyama H
Abstract excerpt
In the HL-60 sublines that were isolated after a long-term continuous culture, abnormally stained or abnormally banded regions on chromosomes replaced extrachromosomal double minutes. The c-MYC gene is amplified in these structures. We followed the c-MYC gene loci during a consecutive passage by using FISH, and have found a large extrachromosomal element (LEE) that preexisted at the earliest passage in a very...
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