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Article

CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A.

Oncogene - 1 Aug 2024

Hu Jinpeng, Li Xinqiao, Xu Kai, Chen Junhua, Zong Shengliang, Zhang Haiying, Li Hao, Zhang Guoqing, Guo Zhengting, Zhao Xiang, Jiang Yang, Jing Zhitao

Abstract excerpt

Exciting breakthroughs have been achieved in the field of glioblastoma with therapeutic interventions targeting specific ferroptosis targets. Nonetheless, the precise mechanisms through which circRNAs regulate the ferroptosis pathway have yet to be fully elucidated. Here we have identified a novel circRNA, circVPS8, which is highly expressed in glioblastoma. Our findings demonstrated that circVPS8 enhances glioma...

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Topics

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Share to Ferroptosis
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatocyte Nuclear Factor 4

Share to Mice, Nude

Share to Neoplastic Stem Cells

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Source

Identifiers

PMID: 39098847
DOI: 10.1038/s41388-024-03116-y

Genes

HNF4A
MKRN1
SOX15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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