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Article

Revisiting the concept of childhood preleukemia.

Trends in cancer - 1 Nov 2022

Cobaleda Cesar, Vicente-Dueñas Carolina, Ramírez-Orellana Manuel, Sanchez-Garcia Isidro

Abstract excerpt

Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing mutations can also be present in differentiated cells unable to transform. We postulate that preleukemia should only be used when such mutations arise in progenitors capable of evolving to B-ALL.

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Identifiers

PMID: 35871053
DOI: 10.1016/j.trecan.2022.06.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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