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Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis.

Stem cell research & therapy - 23 Jul 2022

Xue Chunling, Gao Yang, Li Xuechun, Zhang Mingjia, Yang Ying, Han Qin, Sun Zhao, Bai Chunmei, Zhao Robert Chunhua

Abstract excerpt

BACKGROUND: There is increasing evidence that mesenchymal stem cells (MSCs) help shape the tumor microenvironment and promote tumor progression, and ion channels might play a critical role in this process. The objective of the present study was to explore the function and mechanism of MT-CAFs on progression of colon cancer. METHODS: Here, a gene chip was used for a general analysis of gene expression changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35870973
DOI: 10.1186/s13287-022-03017-5
PMCID: PMC9308187

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