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Cancer-associated fibroblasts-derived exosomal miR-17-5p promotes colorectal cancer aggressive phenotype by initiating a RUNX3/MYC/TGF-β1 positive feedback loop.

Cancer letters - 28 Oct 2020

Zhang Yue, Wang Shanci, Lai Qiuhua, Fang Yuxin, Wu Changjie, Liu Yongfeng, Li Qingyuan, Wang Xinke, Gu Chuncai, Chen Junsheng, Cai Jianqun, Li Aimin, Liu Side

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumour microenvironment (TME). We found that the distribution of CAFs was significantly increased with tumour progression and led to a poor prognosis. In vitro and in vivo assays revealed that CAFs enhanced colorectal cancer (CRC) metastasis. Based on extraction and identification of exosomes of CAFs and normal fibroblasts (NFs), CAFs-exo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32730779
DOI: 10.1016/j.canlet.2020.07.023

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