Article
Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression.
Proteomics - 1 Jan 2013
De Boeck Astrid, Hendrix An, Maynard Dawn, Van Bockstal Mieke, Daniëls Annick, Pauwels Patrick, Gespach Christian, Bracke Marc, De Wever Olivier
Abstract excerpt
The identification of cancer-associated fibroblast (CAF)-derived proteins that mediate interactions between the tumor stroma and cancer cells is a crucial step toward the discovery of new molecular targets for therapy or molecular signatures that improve tumor classification and predict clinical outcome. CAF are α-smooth muscle actin positive, representing a myofibroblast phenotype that may differentiate from...
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