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Article

PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers

24 Jul 2012

Abstract excerpt

PAQR3 is a member of the progestin and adipoQ receptor (PAQR) family and was recently characterized as a spatial regulator that negatively modulates Ras/Raf/MEK/ERK signaling cascade. However, little is known about the physiological functions of PAQR3 in the tumorigenesis of colorectal cancers. The function of PAQR3 in colorectal cancer development in mice was analyzed by crossing Paqr3-depleted mice with...

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PMID: 22828136
DOI: 10.1093/carcin/bgs245

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