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Article

Tumor-associated macrophage-derived transforming growth factor-β promotes colorectal cancer progression through HIF1-TRIB3 signaling.

Cancer science - 1 Oct 2021

Liu Changfu, Zhang Weihao, Wang Junfeng, Si Tongguo, Xing Wenge

Abstract excerpt

Tumor-associated macrophages (TAMs), one of the most common cell components in the tumor microenvironment, have been reported as key contributors to cancer-related inflammation and enhanced metastatic progression of tumors. To explore the underlying mechanism of TAM-induced tumor progression, TAMs were isolated from colorectal cancer patients, and the functional interaction with colorectal cancer cells was...

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PMID: 34375482
DOI: 10.1111/cas.15101
PMCID: PMC8486199

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