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Article

Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2013

Herrera Mercedes, Islam Abul B M M K, Herrera Alberto, Martín Paloma, García Vanesa, Silva Javier, Garcia Jose M, Salas Clara, Casal Ignacio, de Herreros Antonio García, Bonilla Félix, Peña Cristina

Abstract excerpt

PURPOSE: Cancer-associated fibroblasts (CAF) actively participate in reciprocal communication with tumor cells and with other cell types in the microenvironment, contributing to a tumor-permissive neighborhood and promoting tumor progression. The aim of this study is the characterization of how CAFs from primary human colon tumors promote migration of colon cancer cells. EXPERIMENTAL DESIGN: Primary CAF cultures...

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PMID: 24052018
DOI: 10.1158/1078-0432.CCR-13-0694

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