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Article

Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 17 May 2023

He Ruixin, Zheng Ruizhi, Zheng Jie, Li Mian, Wang Tiange, Zhao Zhiyun, Wang Shuangyuan, Lin Hong, Lu Jieli, Chen Yuhong, Xu Yu, Wang Weiqing, Xu Min, Bi Yufang, Ning Guang

Abstract excerpt

CONTEXT: Observational studies indicated obesity and glutamatergic dysfunction as potential risk factors of depression, and reported disturbance of glutamine metabolism in obese state. However, it remains unclear whether the interrelationships between obesity, glutamine, and depression are causal. OBJECTIVE: We conducted 2-sample bidirectional mendelian randomization (MR) analyses to explore the causalities...

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Identifiers

PMID: 36510667
DOI: 10.1210/clinem/dgac707
PMCID: PMC10188313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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