Article
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2022
Long Jaclyn S, Kania Elżbieta, McEwan David G, Barthet Valentin J A, Brucoli Martina, Ladds Marcus J G W, Nössing Christoph, Ryan Kevin M
Abstract excerpt
The role of autophagy in cancer is complex. Both tumor-promoting and tumor-suppressive effects are reported, with tumor type, stage and specific genetic lesions dictating the role. This calls for analysis in models that best recapitulate each tumor type, from initiation to metastatic disease, to specifically understand the contribution of autophagy in each context. Here, we report the effects of deleting the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.