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Personalized Circulating Tumor DNA (ctDNA) Profiling Enables Superior and Universal Measurable Residual Disease (MRD) Detection in Acute Myeloid Leukemia (AML)

2026-02-04

Abstract excerpt

Relapsed and/or refractory disease remains the leading cause of death in AML, highlighting the need for broadly applicable, high-sensitivity approaches to MRD detection. We developed AML-CAPP-Seq ( Ca ncer P ersonalized P rofiling by Deep Seq uencing), a personalized hybrid-capture assay that tracks both canonical AML drivers and patient-specific variants identified by whole-exome sequencing. In 56 patients wi...

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Literature Corpus work: e692f668-952a-55a2-abf1-17b6b5c2653d
DOI: 10.64898/2026.01.28.26344873

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