Article
Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2022
Walker-Sperling Victoria, Digitale Jean C, Viard Mathias, Martin Maureen P, Bashirova Arman, Yuki Yuko, Ramsuran Veron, Kulkarni Smita, Naranbhai Vivek, Li Hongchuan, Anderson Stephen K, Yum Lauren, Clifford Robert, Kibuuka Hannah, Ake Julie, Thomas Rasmi, Rowland-Jones Sarah, Rek John, Arinaitwe Emmanuel, Kamya Moses, Rodriguez-Barraquer Isabel, Feeney Margaret E, Carrington Mary
Abstract excerpt
HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms that regulate TAPBP messenger RNA (mRNA) expression in Africans, rs111686073 (G/C) and rs59097151 (A/G), located in an AP-2α transcription factor binding site and a microRNA (miR)-4486...
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