Article
Preexisting Heterotypic Ligand-blocking Antibody Does Not Protect Against Genogroup II Norovirus Episodes in Young Children.
Journal of the Pediatric Infectious Diseases Society - 25 Oct 2022
Becker-Dreps Sylvia, Brewer-Jensen Paul D, González Fredman, Reyes Yaoska, Mallory Michael L, Gutiérrez Lester, Vielot Nadja A, Diez-Valcarce Marta, Vinjé Jan, Baric Ralph S, Lindesmith Lisa C, Bucardo Filemon
Abstract excerpt
A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.
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