Article
(C)ce(s) haplotype screening in Tunisian blood donors.
Blood transfusion = Trasfusione del sangue - 1 Jul 2014
Moussa Hajer, Ghommen Néjiba, Romdhane Houda, Abdelkefi Saadia, Chakroun Taher, Houissa Batoul, Jemni Saloua Yacoub
Abstract excerpt
BACKGROUND: The (C)ce(s) haplotype, mainly found in black individuals, contains two altered genes: a hybrid RHD-CE-D(s) gene segregated with a ce(s) allele of RHCE with two single nucleotide polymorphisms, c. 733C>G (p.Leu245Val) in exon 5 and c. 1006G>T (Gly336Cys) in exon 7. This haplotype could be responsible for false positive genotyping results in RhD-negative individuals and at a homozygous level lead to...
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