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Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

21 Jun 2022

Abstract excerpt

Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like tyrosine kinase 1 (sFLT1), a validated diagnostic and prognostic marker of the disease when normalized to placental growth factor (PlGF) levels. Injecting cholesterol-conjugated, fully modified, small interfering RNAs (siRNAs) targeting sFLT1 mRNA into pregnant...

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PMID: 35847173
DOI: 10.1016/j.omtn.2022.06.009

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