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Innovative nanoparticle-based approach for preeclampsia treatment through inhibition of KAT7-mediated histone modifications

2025-06-23

Abstract excerpt

Preeclampsia (PE) is a serious pregnancy-related disorder characterized by dysregulated glycolysis and aberrant histone lactylation in the placenta. In this study, we developed folic acid (FA)-modified lipid nanoparticles (FA-LNPs) encapsulating small interfering RNA targeting pyruvate kinase M (si-PKM), termed FA-LNP@si-PKM, to specifically modulate the molecular drivers of PE. Integrated transcriptomic and prote...

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Literature Corpus work
4d3584be-a66a-5df0-b539-03a31889941f
DOI
10.26599/nr.2025.94907706
Open publication

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Innovative nanoparticle-based approach for preeclampsia treatment through inhibition of KAT7-mediated histone modificationsDOI 10.26599/nr.2025.94907706
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