Article
Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 4 Oct 2022
Smith-Byrne Karl, Cerani Agustin, Guida Florence, Zhou Sirui, Agudo Antonio, Aleksandrova Krasimira, Barricarte Aurelio, Barranco Miguel Rodríguez, Bochers Christoph H, Gram Inger Torhild, Han Jun, Amos Christopher I, Hung Rayjean J, Grankvist Kjell, Nøst Therese Haugdhal, Imaz Liher, Chirlaque-López María Dolores, Johansson Mikael, Kaaks Rudolf, Kühn Tilman, Martin Richard M, McKay James D, Pala Valeria, Robbins Hilary A, Sandanger Torkjel M, Schibli David, Schulze Matthias B, Travis Ruth C, Vineis Paolo, Weiderpass Elisabete, Brennan Paul, Johansson Mattias, Richards J Brent
Abstract excerpt
BACKGROUND: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies. MATERIALS AND METHODS: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide association studies (GWAS) of blood metabolite levels (n =...
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