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Article

Structural basis for SHOC2 modulation of RAS signalling.

Nature - 1 Sept 2022

Liau Nicholas P D, Johnson Matthew C, Izadi Saeed, Gerosa Luca, Hammel Michal, Bruning John M, Wendorff Timothy J, Phung Wilson, Hymowitz Sarah G, Sudhamsu Jawahar

Abstract excerpt

The RAS-RAF pathway is one of the most commonly dysregulated in human cancers1-3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of inactive RAF monomer5 and active RAF dimer5-8 bound to 14-3-39,10 have revealed the mechanisms by which 14-3-3 stabilizes both RAF conformations via specific...

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Identifiers

PMID: 35768504
DOI: 10.1038/s41586-022-04838-3
PMCID: PMC9452301

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