SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency.

doi:10.1007/s00018-022-04429-5

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Article

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency.

Cellular and molecular life sciences : CMLS - 11 Jul 2022

Carrizzo Albino, Iside Concetta, Nebbioso Angela, Carafa Vincenzo, Damato Antonio, Sciarretta Sebastiano, Frati Giacomo, Di Nonno Flavio, Valenti Valentina, Ciccarelli Michele, Venturini Eleonora, Scioli Mariarosaria, Di Pietro Paola, Bucci Tommaso, Giudice Valentina, Storto Marianna, Serio Bianca, Puca Annibale Alessandro, Giugliano Giuseppe, Trimarco Valentina, Izzo Raffaele, Trimarco Bruno, Selleri Carmine, Altucci Lucia, Vecchione Carmine

Abstract excerpt

Beyond well-assessed risk factors, cardiovascular events could be also associated with the presence of epigenetic and genetic alterations, such as the methylenetetrahydrofolate-reductase (MTHFR) C677T polymorphism. This gene variant is related to increased circulating levels of homocysteine (Hcy) and cardiovascular risk. However, heterozygous carriers have an augmented risk of cardiovascular accidents...

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Identifiers

PMID: 35821533
DOI: 10.1007/s00018-022-04429-5
PMCID: PMC9276577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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