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Article

Assessment of the Causal Effect of IgG N-Glycosylation Level on Risk of Dementia: A 2-Sample Mendelian Randomization Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Zhang Xiaoyu, Cong Ruyi, Geng Tao, Zhang Jinxia, Liu Di, Tian Qiuyue, Meng Xiaoni, Song Manshu, Wu Lijuan, Zheng Deqiang, Wang Wei, Wang Baoguo, Wang Youxin

Abstract excerpt

BACKGROUND: Previous prospective studies highlighted aberrant immunoglobulin G (IgG) N-glycosylation as a risk factor for dementia [such as Alzheimer's disease (AD) and vascular dementia (VaD)]. It is unclear whether this association is causal or explained by confounding or reverse causation. OBJECTIVE: The aim is to examine the association of genetically predicted IgG N-glycosylation with dementia using 2-sample...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35811520
DOI: 10.3233/JAD-220074

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