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Article

Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine

7 Jul 2022

Abstract excerpt

Humans frequently encounter Staphylococcus aureus (SA) throughout life. Animal studies have yielded SA candidate vaccines, yet all human SA vaccine trials have failed. One notable vaccine "failure" targeted IsdB, critical for host iron acquisition. We explored a fundamental difference between humans and laboratory animals-natural SA exposure. Recapitulating the failed phase III IsdB vaccine trial, mice previously...

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PMID: 35803276
DOI: 10.1016/j.chom.2022.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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