Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy

Abstract excerpt

Abstract Staphylococcus aureus infections are a major public health issue, and a vaccine is urgently needed. Despite a considerable promise in preclinical models, all vaccines tested thus far have failed to protect humans against S. aureus . Unlike laboratory mice, humans are exposed to S. aureus throughout life. In the current study, we hypothesized that prior exposure to S. aureus “imprints” the immune response...

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