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Article

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire

18 Nov 2016

Abstract excerpt

Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the memory humoral response against IsdB, a protein involved in iron acquisition, in four healthy donors. Here we show that in all donors a heavily biased use of two immunoglobulin heavy chain germlines generated high affinity (pM) antibodies that neutralize the...

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PMID: 27857134
DOI: 10.1038/ncomms13376

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