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Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation

15 Dec 2024

Abstract excerpt

Despite many attempts, there is currently no approved vaccine to prevent Staphylococcus aureus infections. Preclinical vaccination models have failed to predict vaccine efficacy in humans as S. aureus exposure in humans imprints an immune response that is lacking in naive animals. In this issue of the JCI, Tsai and colleagues identify the cytokine IL-10 as the driver of humoral imprinting by S. aureus. Upon...

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PMID: 39680461
DOI: 10.1172/jci187055

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