Article
Distinct genetic forms of frontotemporal dementia.
Neurology - 14 Oct 2008
Seelaar H, Kamphorst W, Rosso S M, Azmani A, Masdjedi R, de Koning I, Maat-Kievit J A, Anar B, Donker Kaat L, Breedveld G J, Dooijes D, Rozemuller J M, Bronner I F, Rizzu P, van Swieten J C
Abstract excerpt
BACKGROUND: Frontotemporal dementia (FTD) is the second most common type of presenile dementia and can be distinguished into various clinical variants. The identification of MAPT and GRN defects and the discovery of the TDP-43 protein in FTD have led to the classification of pathologic and genetic subtypes. In addition to these genetic subtypes, there exist familial forms of FTD with unknown genetic defects....
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