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Assessment of the TGFB1 gene expression and methylation status of the promoter region in patients with colorectal cancer

7 Jul 2022

Abstract excerpt

The aim of this study was to evaluate the expression of the TGFB1 gene encoding the TGF-β1 cytokine in 64 patients, and then to compare it with clinico-pathological features. The study also investigated whether the regulation of the gene expression is caused by methylation of the promoter region between - 235 and + 22 nucleotide from the start of transcription. The dependence of the relative level of the TGFB1...

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PMID: 35798776
DOI: 10.1038/s41598-022-15599-4

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