Article
Impact of TGF-β1 expression and -509C>T polymorphism in the TGF-β1 gene on the progression and survival of gastric cancer.
Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2000
Ananiev Julian, Manolova Irena, Aleksandrova Elina, Gulubova Maya
Abstract excerpt
The aim of this study was to examine the expression of TGF-β1 and TGF-β receptor type II (RII) and the impact of the -509C>T single nucleotide polymorphism (SNP) in the gene in relation to clinicopathological factors in gastric cancer (GC). Using immunohistochemistry we investigated 43 patients with GC for expression of TGF-β1 and TGF-β-RII. Consequently, RFLP-PCR was performed to analyze the presence of -509C>T...
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