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Article

NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Like Disease.

The Journal of investigative dermatology - 1 Jun 2021

Zhu Feng, Willette-Brown Jami, Zhang Jian, Ferre Elise M N, Sun Zhonghe, Wu Xiaolin, Lionakis Michail S, Hu Yinling

Abstract excerpt

Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy show diverse endocrine and nonendocrine manifestations initiated by self-reactive T cells because of AIRE mutation-induced defective central tolerance. A large number of American patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy suffer from early-onset cutaneous inflammatory lesions accompanied by an...

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Identifiers

PMID: 33188780
DOI: 10.1016/j.jid.2020.10.016
PMCID: PMC8110612

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