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Article

Reduced frequencies of Foxp3+GARP+ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype.

Respiratory research - 2 Jul 2022

Hou Jia, Wang Xia, Su Chunxia, Ma Weirong, Zheng Xiwei, Ge Xiahui, Duan Xiangguo

Abstract excerpt

BACKGROUND: Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, indicating that GARP is a marker for bona fide Tregs. A different phenotype of chronic obstructive pulmonary disease (COPD) may have a different immunologic mechanism. OBJECTIVE: To investigate...

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Identifiers

PMID: 35780120
DOI: 10.1186/s12931-022-02099-2
PMCID: PMC9250745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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