Article
Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.
Respiratory research - 14 Dec 2020
Eriksson Ström Jonas, Pourazar Jamshid, Linder Robert, Blomberg Anders, Lindberg Anne, Bucht Anders, Behndig Annelie F
Abstract excerpt
BACKGROUND: Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time lead to chronic inflammation and COPD. We hypothesized that-among COPD patients-the same...
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