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Article

Regulatory T Cell-Related Gene Polymorphisms are Associated with Risk of Lung Cancer in Patients with COPD.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Zhang Xia, Chen Fei

Abstract excerpt

Background: The chronic inflammatory state of COPD can lead to an imbalance in immune cell subsets, specifically manifested as an increase in regulatory T cells (Tregs), which may promote tumor immune escape. However, few studies have reported the correlation between polymorphisms of Treg-related FOXP3, IL2, and TGFB1 genes and the risk of lung cancer in COPD patients. Methods: Six SNPs in FOXP3, IL2, and TGFB1...

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Source

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Identifiers

PMID: 42117055
DOI: 10.2147/COPD.S598516
PMCID: PMC13157840

Genes

FOXP3
IL2
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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