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Article

POLQ suppresses genome instability and alterations in DNA repeat tract lengths

29 Jun 2022

Abstract excerpt

Abstract DNA polymerase theta (POLQ) is a principal component of the alternative non-homologous end-joining (ANHEJ) DNA repair pathway that ligates DNA double-strand breaks. Utilizing independent models of POLQ insufficiency during telomere-driven crisis, we found that POLQ–/– cells are resistant to crisis-induced growth deceleration despite sustaining inter-chromosomal telomere fusion frequencies equivalent to...

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Identifiers

PMID: 35774233
DOI: 10.1093/narcan/zcac020

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