Article
Inheritance of wild and truncated DAT alleles from grand-parents: Opposite transgenerational consequences on the behavioral phenotype in adolescent DAT heterozygous rats.
Neuroscience letters - 27 Jul 2023
Puzzo Concetto, D'Angiò Roberta, Albanese Sara, Orlando Daniela, Mangili Ileana, Capobianco Micaela, Liberati Anna Sara, Adriani Walter
Abstract excerpt
Dopamine plays important roles in implicit memory and motivation of behavior. Environmental inputs can produce transgenerational epigenetic changes. This concept also includes the uterus: experimentally, we sought to create hyper-dopaminergic uterine conditions through ineffective dopamine-transporter (DAT) protein, obtained by inserting a stop-codon into the SLC6A3 gene. By crossing WT-dam with KO-sire (or...
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