Article
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality.
American journal of respiratory and critical care medicine - 15 Nov 2022
Verma Anurag, Minnier Jessica, Wan Emily S, Huffman Jennifer E, Gao Lina, Joseph Jacob, Ho Yuk-Lam, Wu Wen-Chih, Cho Kelly, Gorman Bryan R, Rajeevan Nallakkandi, Pyarajan Saiju, Garcon Helene, Meigs James B, Sun Yan V, Reaven Peter D, McGeary John E, Suzuki Ayako, Gelernter Joel, Lynch Julie A, Petersen Jeffrey M, Zekavat Seyedeh Maryam, Natarajan Pradeep, Dalal Sharvari, Jhala Darshana N, Arjomandi Mehrdad, Gatsby Elise, Lynch Kristine E, Bonomo Robert A, Freiberg Matthew, Pathak Gita A, Zhou Jin J, Donskey Curtis J, Madduri Ravi K, Wells Quinn S, Huang Rose D L, Polimanti Renato, Chang Kyong-Mi, Liao Katherine P, Tsao Philip S, Wilson Peter W F, Hung Adriana M, O'Donnell Christopher J, Gaziano John M, Hauger Richard L, Iyengar Sudha K, Luoh Shiuh-Wen
Abstract excerpt
Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome coronavirus 2 infection and disease severity is unclear. Objectives: To assess whether rs35705950-T confers differential risk for clinical outcomes associated with coronavirus disease (COVID-19) infection among participants in the Million Veteran...
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