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Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.

mBio - 31 Aug 2021

Ries Laure Nicolas Annick, Alves de Castro Patricia, Pereira Silva Lilian, Valero Clara, Dos Reis Thaila Fernanda, Saborano Raquel, Duarte Iola F, Persinoti Gabriela Felix, Steenwyk Jacob L, Rokas Antonis, Almeida Fausto, Costa Jonas Henrique, Fill Taicia, Sze Wah Wong Sarah, Aimanianda Vishukumar, Rodrigues Fernando José Santos, Gonçales Relber A, Duarte-Oliveira Cláudio, Carvalho Agostinho, Goldman Gustavo H

Abstract excerpt

Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use host carbon sources, such as acetate, present in the body fluids and peripheral tissues. However, utilization of acetate as a carbon source by fungi in the context of infection has not been investigated. This work shows that acetate is...

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Identifiers

PMID: 34311583
DOI: 10.1128/mBio.01682-21
PMCID: PMC8406206

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