An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma.

doi:10.1182/bloodadvances.2023011213

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Article

An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma.

Blood advances - 12 Mar 2024

Flümann Ruth, Hansen Julia, Meinel Jörn, Pfeiffer Pauline, Goldfarb Wittkopf Hannah, Lütz Anna, Wirtz Jessica, Möllmann Michael, Zhou Tanja, Tabatabai Areya, Lohmann Tim, Jauch Maximilian, Beleggia Filippo, Pelzer Benedikt, Ullrich Fabian, Höfmann Svenja, Arora Aastha, Persigehl Thorsten, Büttner Reinhard, von Tresckow Bastian, Klein Sebastian, Jachimowicz Ron D, Reinhardt Hans Christian, Knittel Gero

Abstract excerpt

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma and constitutes a highly heterogenous disease. Recent comprehensive genomic profiling revealed the identity of numerous molecularly defined DLBCL subtypes, including a cluster which is characterized by recurrent aberrations in MYD88, CD79B, and BCL2, as well as various lesions promoting a block in plasma cell differentiation,...

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PMID: 38060829
DOI: 10.1182/bloodadvances.2023011213
PMCID: PMC10907402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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