Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

A Membranome-Centered Approach Defines Novel Biomarkers for Cellular Subtypes in the Intervertebral Disc.

Cartilage - 1 Apr 2020

van den Akker Guus G H, Eijssen Lars M T, Richardson Stephen M, Rhijn Lodewijk W van, Hoyland Judith A, Welting Tim J M, Voncken Jan Willem

Abstract excerpt

OBJECTIVE: Lack of specific marker-sets prohibits definition and functional distinction of cellular subtypes in the intervertebral disc (IVD), such as those from the annulus fibrosus (AF) and the nucleus pulposus (NP). DESIGN: We recently generated immortalized cell lines from human NP and AF tissues; these comprise a set of functionally distinct clonal subtypes. Whole transcriptome analyses were performed of 12...

Topics

Annulus Fibrosus
Cell Line
Chondrocytes
Gene Expression Profiling
Genetic Markers
Humans
Intervertebral Disc
Nucleus Pulposus
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 29629573
DOI: 10.1177/1947603518764260
PMCID: PMC7097986

Genes

IVD
ANXA2
CHIC1
CLDN11
COLEC12
EFNA1
LPAR1
NETO2
TMEFF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Membranome-Centered Approach Defines Novel Biomarkers for Cellular Subtypes in the Intervertebral Disc.PMID 29629573Read ↗

Single-cell atlas unveils cellular heterogeneity and novel markers in human neonatal and adult intervertebral discsSemantic proximity Read ↗

Single-cell Atlas Unveils Cellular Heterogeneity and Novel Markers in Human Neonatal and Adult Intervertebral DiscsSemantic proximity Read ↗

Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cellsSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc DegenerationSemantic proximity Read ↗

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration ProgressionSemantic proximity Read ↗

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degenerationSemantic proximity Read ↗

Novel Immortal Cell Lines Support Cellular Heterogeneity in the Human Annulus FibrosusSemantic proximity Read ↗

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progressionSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc DegenerationSemantic proximity Read ↗

Novel immortal human cell lines reveal subpopulations in the nucleus pulposusSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular InteractionsSemantic proximity Read ↗

Single-cell sequencing: New insights for intervertebral disc degenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.