Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degeneration

13 Sept 2024

Abstract excerpt

Low back pain (LBP) is largely attributed to intervertebral disc degeneration (IVDD), of which the endplate changes are an important component. However, the alterations in cell fate and properties within the endplates during degeneration remain unknown. Here, we firstly performed the single-cell RNA-sequencing analysis (scRNA-seq) of the cells focusing on degenerative human endplates. By unsupervised clustering...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical and Thoracic Myelopathy
Share to Scoliosis diagnosis and treatment
Share to Spine and Intervertebral Disc Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39271714
DOI: 10.1038/s41598-024-71891-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degenerationPMID 39271714Read ↗

Single-cell sequencing: New insights for intervertebral disc degenerationSemantic proximity Read ↗

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degenerationSemantic proximity Read ↗

Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypesSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular InteractionsSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc DegenerationSemantic proximity Read ↗

Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc DegenerationSemantic proximity Read ↗

Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc DegenerationSemantic proximity Read ↗

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discsSemantic proximity Read ↗

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedicsSemantic proximity Read ↗

Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degenerationSemantic proximity Read ↗

Single-cell RNA sequencing in orthopedic researchSemantic proximity Read ↗

Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.