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Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β‐catenin signaling pathway

23 Jun 2022

Abstract excerpt

Intervertebral disc (IVD) degeneration (IVDD) is closely linked to degenerative spinal disease, resulting in disability, poor quality of life, and financial burden. Apoptosis of nucleus pulposus (NP) cells (NPCs) is a key pathological basis of IVDD. Periostin (POSTN), an extracellular matrix protein, is expressed in many tissues, whereas its abnormal expression is associated with IVDD. The conventional...

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PMID: 35747912
DOI: 10.1096/fj.202200123r

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