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Article

FBXW7 mediates intervertebral disc degeneration by regulating the JNK signaling pathway to induce nucleus pulposus cell apoptosis

2025-10-20

Abstract excerpt

<title>Abstract</title> <p>Objective Elucidating the mechanistic role of FBXW7 in JNK pathway activation and subsequent nucleus pulposus apoptosis during disc degeneration. Background NPCs apoptosis constitutes a core pathological event during disc degeneration. Oxidative stress triggers JNK-mediated apoptotic signaling cascades in nucleus pulposus cells. As a core E3 ligase component, FBXW7 is involved in apopto...

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Literature Corpus work
a5dc123f-59cd-5da6-b451-0918ee0812f6
DOI
10.21203/rs.3.rs-7518753/v1
Open publication

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