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Article

Resistance to chemotherapy: new treatments and novel insights into an old problem

29 Jul 2008

Abstract excerpt

Resistance to cancer chemotherapeutic treatment is a common phenomenon, especially in progressive disease. The generation of cellular models of drug resistance has been pivotal in unravelling the main effectors of resistance to traditional chemotherapy at the molecular level (i.e. intracellular drug inactivation, detoxifying systems, defects in DNA repair, apoptosis evasion, membrane transporters and cell...

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PMID: 18665178
DOI: 10.1038/sj.bjc.6604510

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