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Article

Characteristics of patients with late manifestation of resistance thyroid hormone syndrome: a single-center experience.

Endocrine - 1 Dec 2015

Han Rulai, Ye Lei, Jiang Xiaohua, Zhou Xiaoyi, Billon Cyrielle, Guan Wenyue, Gauthier Karine, Fang Weiyuan, Wang Weiqing, Samarut Jacques, Ning Guang

Abstract excerpt

Resistance to thyroid hormone (RTH) is a rare genetic disease caused by reduced tissue sensitivity to thyroid hormone. The hallmark of RTH is elevated serum levels of thyroid hormone with unsuppressed thyrotropin (TSH). However, the most common form of RTH results from minor defects in the ligand-binding domain or hinge domain of the TRβ gene, resulting in impaired T3-induced transcriptional activity, often...

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Identifiers

PMID: 26041374
DOI: 10.1007/s12020-015-0622-x

Genes

TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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